Nucleotide-Specific Contrast for DNA Sequencing by Electron Spectroscopy
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چکیده
منابع مشابه
Nucleotide-Specific Contrast for DNA Sequencing by Electron Spectroscopy
DNA sequencing by imaging in an electron microscope is an approach that holds promise to deliver long reads with low error rates and without the need for amplification. Earlier work using transmission electron microscopes, which use high electron energies on the order of 100 keV, has shown that low contrast and radiation damage necessitates the use of heavy atom labeling of individual nucleotid...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0154707